Cyclo(L-Pro-L-Trp-)

CAS NO.：38136-70-8
Empirical Formula: C16H17N3O2
Molecular Weight: 283.33
MDL number: MFCD29917326
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:53:19

What is Cyclo(L-Pro-L-Trp-)?

Description

Brevianamide F is an alkaloid metabolite produced by various Streptomyces, Actinomycetes, and Aspergillus strains that has diverse biological activities. It inhibits growth of M. luteus and S. aureus in an inhibitory disc assay when used at a concentration of 30 μg/disc as well as the Bacille Calmette-Guerin M. bovis strain (MIC = 12.5 μg/ml). Brevianamide F has antifouling activity, inhibiting attachment of B. neritina larvae to PVC plates without inducing lethality (EC₅₀ = 6.35 μg/ml; LC₅₀ = >200 μg/ml in paint used to coat PVC plates).

The Uses of Cyclo(L-Pro-L-Trp-)

Brevianamide F is used in the preparation, reactions, medicinal and cheical propreties of diketopiperazines as bioactive natural products. Acts as a reagent in the total synthesis and antitumor activity in vitro of glioperazine C and its derivatives, synthesis and biological evaluation of a post-synthetically trp-based diketopiperazine and it’s antitumor structure-activity relationship.

Definition

ChEBI: A pyrrolopyrazine that is hexahydropyrrolo[1,2-a]pyrazine-1,4-dione bearing an indol-3-ylmethyl substituent at position 3 (the 3S,8aS-diastereomer, obtained by formal cyclocondensation of L-tr ptophan and L-proline).

Properties of Cyclo(L-Pro-L-Trp-)

Melting point:	165-167 °C
Boiling point:	633.2±48.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	13.20±0.40(Predicted)
color	White to Off-White

Safety information for Cyclo(L-Pro-L-Trp-)

Computed Descriptors for Cyclo(L-Pro-L-Trp-)

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