CYCLO(-LEU-PRO)
- CAS NO.：2873-36-1
- Empirical Formula: C11H18N2O2
- Molecular Weight: 210.27
- MDL number: MFCD00237617
- EINECS: 220-710-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 16:31:51
What is CYCLO(-LEU-PRO)?
Description
Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.
Chemical properties
White Solid
The Uses of CYCLO(-LEU-PRO)
Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.
What are the applications of Application
Cyclo(-Leu-Pro) is a cyclic dipeptide containing leucine and proline
Definition
ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.
Properties of CYCLO(-LEU-PRO)
| Melting point: | 163-165℃ |
| Boiling point: | 427.6±34.0 °C(Predicted) |
| Density | 1.14 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.27±0.40(Predicted) |
| color | White to Off-White |
Safety information for CYCLO(-LEU-PRO)
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for CYCLO(-LEU-PRO)
New Products
Tridecanoic acid 3-Bromophenylacetic acid 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Hendecanoic acid 2-Amino-5-cyanopyridine 2-Bromo-5-cyanopyridine 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 5-Bromo-4-chloro-3-indolyl-β-D-galactopyranoside Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 3′-Hydroxyacetophenone 5-fluoro-1,3-benzodioxole 2-Bromo-6-fluoroaniline Methyl-5-chloro-2-hdyroxy-3-nitro benzoate 5-(2,4-Difluorophenyl) isoxazole-3-carboxylicacid Methyl-5-(3-nitrophenyl)isoxazole-3-carboxylate 2-Bromo-1-(5-fluoro-2-hydroxyphenyl)ethanone Methl-4-(chlorophenyl)-2,4-dioxo butanoate 2-Morpholino nicotinicacid 5-amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile ethyl 1-(6-chloropyridin-2-yl)-5-hydroxy-1H-pyrazole-4-carboxylate N-[-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-(methyl-d3)-1-naphthalenemethanamine, monohydrochloride 2H-indol-2-one, 5-amino-1,3-dihydro-1-(1-methylethyl)- Nifedipine D6Related products of tetrahydrofuran
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