CYCLO(-LEU-PRO)

CAS NO.：2873-36-1
Empirical Formula: C11H18N2O2
Molecular Weight: 210.27
MDL number: MFCD00237617
EINECS: 220-710-6
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-03 11:24:09

What is CYCLO(-LEU-PRO)?

Description

Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC₅₀ value of 0.15 mM.

Chemical properties

White Solid

The Uses of CYCLO(-LEU-PRO)

Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.

What are the applications of Application

Cyclo(-Leu-Pro) is a cyclic dipeptide containing leucine and proline

Definition

ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.

Properties of CYCLO(-LEU-PRO)

Melting point:	163-165℃
Boiling point:	427.6±34.0 °C(Predicted)
Density	1.14
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form	Solid
pka	13.27±0.40(Predicted)
color	White to Off-White

Safety information for CYCLO(-LEU-PRO)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection.