CYCLO(-LEU-PRO)
- CAS NO.：2873-36-1
- Empirical Formula: C11H18N2O2
- Molecular Weight: 210.27
- MDL number: MFCD00237617
- EINECS: 220-710-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is CYCLO(-LEU-PRO)?
Description
Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.
Chemical properties
White Solid
The Uses of CYCLO(-LEU-PRO)
Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.
What are the applications of Application
Cyclo(-Leu-Pro) is a cyclic dipeptide containing leucine and proline
Definition
ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.
Properties of CYCLO(-LEU-PRO)
| Melting point: | 163-165℃ |
| Boiling point: | 427.6±34.0 °C(Predicted) |
| Density | 1.14 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.27±0.40(Predicted) |
| color | White to Off-White |
Safety information for CYCLO(-LEU-PRO)
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for CYCLO(-LEU-PRO)
New Products
Cyclopropane-1,1-dicarboxylic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity tert-Butyl (2S)-[1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate 4-amino-2-fluoro-N- methylbenzamide 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine N-Boc-1,4-butanediamine 4-Bromo-2-fluoro-N-methylbenzamide valeronitrile 3-chlorobenzyl cyanide 3,4 Dimethoxy Benzylcyanide 3,4 Diethoxy Benzylcyanide 2-Chloro Benzylcyanide 3-Hydroxypropionitrile 5-azidovalericacid 6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (4-Methoxyphenyl) hydrazine HydrochlorideRelated products of tetrahydrofuran
![(S)-1,4-DIAZABICYCLO[4.3.0]NONANE](https://img.chemicalbook.in/CAS/GIF/93643-24-4.gif)
![hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one](https://img.chemicalbook.in/CAS/20150408/GIF/1000577-63-8.gif)
![(+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE](https://img.chemicalbook.in/CAS/GIF/5654-83-1.gif)
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