CYCLO(-LEU-PRO)
- CAS NO.：2873-36-1
- Empirical Formula: C11H18N2O2
- Molecular Weight: 210.27
- MDL number: MFCD00237617
- EINECS: 220-710-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-29 15:43:00
What is CYCLO(-LEU-PRO)?
Description
Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.
Chemical properties
White Solid
The Uses of CYCLO(-LEU-PRO)
Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.
What are the applications of Application
Cyclo(-Leu-Pro) is a cyclic dipeptide containing leucine and proline
Definition
ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.
Properties of CYCLO(-LEU-PRO)
| Melting point: | 163-165℃ |
| Boiling point: | 427.6±34.0 °C(Predicted) |
| Density | 1.14 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.27±0.40(Predicted) |
| color | White to Off-White |
Safety information for CYCLO(-LEU-PRO)
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for CYCLO(-LEU-PRO)
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