CYCLO(-HIS-PRO)
- CAS NO.：53109-32-3
- Empirical Formula: C11H14N4O2
- Molecular Weight: 234.25
- MDL number: MFCD00133207
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-23 14:48:42
What is CYCLO(-HIS-PRO)?
The Uses of CYCLO(-HIS-PRO)
Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity.
What are the applications of Application
Cyclo(-His-Pro) is a cyclic dipeptide containing histidine and proline
Definition
ChEBI: Cyclo(L-His-L-Pro) is a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). It has a role as a human blood serum metabolite, a dopamine uptake inhibitor and an anti-inflammatory agent. It is a homodetic cyclic peptide, a dipeptide, a pyrrolopyrazine and a member of imidazoles. It is functionally related to a L-histidine and a L-proline.
Properties of CYCLO(-HIS-PRO)
| Melting point: | 162-164 °C |
| Boiling point: | 659.3±48.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml |
| form | A neat oil |
| pka | 12.73±0.40(Predicted) |
| color | Light yellow to yellow |
Safety information for CYCLO(-HIS-PRO)
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CYCLO(-HIS-PRO)
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