CU-32
- CAS NO.：2400954-16-5
- Empirical Formula: C11H10IN5O2
- Molecular Weight: 371.13
- Update Date: 2026-07-16 07:06:08
What is CU-32?
Biological Activity
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50 = 0.45 μM).1 It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.
References
1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)
Properties of CU-32
| Boiling point: | 537.0±52.0 °C(Predicted) |
| Density | 1.880±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml |
| form | A crystalline solid |
| pka | 3.11±0.10(Predicted) |
Safety information for CU-32
Computed Descriptors for CU-32
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