CTOP
- CAS NO.：103429-31-8
- Empirical Formula: C50H67N11O11S2
- Molecular Weight: 1062.26
- MDL number: MFCD00076708
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-20 15:44:38
What is CTOP?
The Uses of CTOP
CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.
The Uses of CTOP
CTOP has been used:
- to study the anxiogenic effects induced by CTOP in mice and rat.
- to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
- to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).
General Description
D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.
Biochem/physiol Actions
Selective ligand for μ-opioid receptors.
Storage
Store at -20°C
Properties of CTOP
| Boiling point: | 1491.2±65.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| RTECS | XO8578200 |
| storage temp. | -20°C |
| pka | 9.90±0.15(Predicted) |
| form | Powder |
| Water Solubility | Soluble to 1 mg/ml in water |
Safety information for CTOP
Computed Descriptors for CTOP
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