Creatine ethyl ester hydrochloride

CAS NO.：15366-32-2
Empirical Formula: C6H14ClN3O2
Molecular Weight: 195.65
MDL number: MFCD08704792
EINECS: 000-000-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-24 18:11:58

What is Creatine ethyl ester hydrochloride?

Synthesis

Creatine ethyl ester hydrochloride is prepared by the reaction of ethanol and creatine. The specific synthesis steps are as follows:
Phosphorochloridic acid (2.0-2.5 equivalents to creatine) was added dropwise to a suspension of creatine in 10 mL of ethanol at 0° C. The reaction mixture was stirred for 15 min at 0° C. and the temperature then raised to 60° C. and stirred for 30 min. The reaction mixture was then cooled to provide 1.7 g of the hydrochloride salt of title compound (24) (73percent yield) as a white solid. 1H NMR (CD3OD, 400 MHz): δ 4.20-4.30 (m, 4H), 3.16(s, 3H, creatinine NCH3), 3.08 (s, 3H, CBE NCH3), 1.31 (d, J=6.8 Hz), (CBE/creatinine=9:1).
Creatine ethyl ester hydrochloride synthesis

Properties of Creatine ethyl ester hydrochloride

Melting point:	162-165°C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C

Safety information for Creatine ethyl ester hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.