CPNQ

Synonym(s):5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline;B2

CAS NO.：115687-05-3
Empirical Formula: C20H17ClN4O3
Molecular Weight: 396.83
MDL number: MFCD02039810
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:28:46

What is CPNQ?

The Uses of CPNQ

B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). Multidrug resistance protein 4 (MRP4) inhibitor in tumors such as neuroblastoma and colorectal cancer.

What are the applications of Application

B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2)

Definition

ChEBI: (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone is a N-arylpiperazine.

Biological Activity

Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α -synuclein-mediated toxicity.

Properties of CPNQ

Melting point:	174-176°C
Boiling point:	645.5±55.0 °C(Predicted)
Density	1.412±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	H2O: insoluble <2mg/mL
pka	2.30±0.29(Predicted)
form	solid
color	brown

Safety information for CPNQ

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.