Conduritol B epoxide

Synonym(s):1,2-Anhydro-myo-inositol;CBE, 1,2-Anhydro-myo-inositol;Conduritol B Epoxide - CAS 6090-95-5 - Calbiochem

CAS NO.：6090-95-5
Empirical Formula: C6H10O5
Molecular Weight: 162.14
MDL number: MFCD00077326
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:53:29

What is Conduritol B epoxide?

Description

Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4.

Chemical properties

White Crystalline Solid

The Uses of Conduritol B epoxide

Conduritol B Epoxide acts on b-glucosidases from widely differing sources to show a loss of enzymic activity: from various Aspergillus species, yeast, snail, sweet almonds, and mammals. The other enzymes that have been found to be covalently inhibited are a- glucosidase from yeast and the sucrase-isomaltase complex from rabbit small intestine.

The Uses of Conduritol B epoxide

inhibitor of glucosidases

What are the applications of Application

Conduritol B Epoxide (CBE) is a specific covalent β-glycosidase enzyme inhibitor that results in the accumulation of glucocerebroside.

Definition

ChEBI: 1-D-1,2-anhydro-myo-inositol is a conduritol epoxide resulting from the formal epoxidation of the double bond of (+)-conduritol B. It has a role as an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor and an EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor. It is functionally related to a (+)-conduritol B. It is an enantiomer of a 1-L-1,2-anhydro-myo-inositol.

General Description

Conduritol B epoxide?(CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.

Biochem/physiol Actions

Conduritol B epoxide?(CBE)?is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).

Storage

Store at -20°C

References

1) Datta and Radin (1988), Normalization of liver glucosylceramide levels in the “Gaucher” mouse by phosphatidylserine injection;? Biochem. Biophys. Res. Commun., 152 155 2) Radin and Vunnam (1981), Inhibitors of cerebroside metabolism;? Methods Enzymol., 72 673 3) Stephens et al. (1981), Distribution of conduritol B epoxide in the animal model for gaucher’s disease (Gaucher mouse); Biochim. Biophys. Acta, 672 29 4) Newburg et al. (1986), beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell;? Biochim. Biophys. Acta, 877 121

Properties of Conduritol B epoxide

Melting point:	157-159
Boiling point:	360.5±42.0 °C(Predicted)
Density	1.925±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	2-8°C
solubility	Soluble in Water (up to 25 mg/ml) or in DMSO
pka	13.08±0.70(Predicted)
form	White solid
color	White
Stability:	Moisture Sensitive

Safety information for Conduritol B epoxide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.