Closantel
Synonym(s):N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide;5′-Chloro-4′-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2′-methylsalicylanilide
- CAS NO.：57808-65-8
- Empirical Formula: C22H14Cl2I2N2O2
- Molecular Weight: 663.07
- MDL number: MFCD00661151
- EINECS: 260-967-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-20 10:51:09
What is Closantel?
Chemical properties
White to light yellow powder
The Uses of Closantel
antianginal, antihypertensive
What are the applications of Application
Closantel is potentially useful for studying P-glycoprotein interactions in vitro
Definition
ChEBI: N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide is an aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. It is a nitrile, a member of phenols, an organoiodine compound, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.
Properties of Closantel
| Melting point: | 217.8° |
| Boiling point: | 590.5±50.0 °C(Predicted) |
| Density | 1.8759 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml |
| pka | 5.99±0.48(Predicted) |
| form | neat |
| form | Solid |
| color | White to off-white |
| CAS DataBase Reference | 57808-65-8(CAS DataBase Reference) |
Safety information for Closantel
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H413:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Closantel
Closantel manufacturer
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