clofibride

Originator

Lipenan,Charpentier,France,1974

Definition

ChEBI: Clofibride is a monocarboxylic acid.

Manufacturing Process

48.5 parts of ethyl 4'-chlorophenoxyisobutyrate are dissolved in 200 parts by volume of dry toluene in the presence of 262 parts of 4-hydroxy-N,Ndimethylbutyramide and 2 parts of aluminum isopropylate. The solution is heated for 8 hours, while collecting the toluene-ethanol azeotrope, in an apparatus provided with a distillation column at a controllable rate of reflux. After this it is filtered ,the solvent is evaporated in vacuo and the residue is distilled. An almost colorless, slightly yellow oil is obtained, the purity of which by chromatographic examination in the gaseous phase is of the order of 99.5%. Its boiling point is 175°C under 0.1 torr.
48.5 parts of ethyl 4'-chlorophenoxyisobutyrate are dissolved in 200 parts by volume of dry toluene in the presence of 262 parts of 4-hydroxy-N,Ndimethylbutyramide and 2 parts of aluminum isopropylate. The solution is heated for 8 hours, while collecting the toluene-ethanol azeotrope, in an apparatus provided with a distillation column at a controllable rate of reflux. After this it is filtered ,the solvent is evaporated in vacuo and the residue is distilled. An almost colorless, slightly yellow oil is obtained, the purity of which by chromatographic examination in the gaseous phase is of the order of 99.5%. Its boiling point is 175°C under 0.1 torr.
The product can be recrystallized. For this, it is dissolved, for example, at the ambient temperature in petrol ether, ethyl ether or isopropyl ether, and this solution is cooled at about -50°C while stirring. After drying over sulfuric acid under vacuum, white needles of very great purity are thus obtained.

Therapeutic Function

Antihyperlipidemic