clitocine

CAS NO.：105798-74-1
Empirical Formula: C9H13N5O6
Molecular Weight: 287.231
MDL number: MFCD00875657
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-04 19:55:51

What is clitocine?

Definition

ChEBI: Clitocine is a N-glycosyl compound.

Biological Activity

Clitocine, an adenosine nucleoside analog derived from mushrooms, is a potent readthrough. As an inhibitor of nonsense mutations, it can induce the production of p53 protein in cells carrying p53 nonsense mutant alleles. It induces apoptosis in multidrug-resistant tumor cells by targeting Mcl-1. Has anticancer activity.

in vitro

Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough.
Clitocine (0-0.8 μM ; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. It (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis.

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in vivo

Citocine (0.3-3 mg/kg; sc; five times per week)-induced p53 inhibits CAOV-33 _p53-UAA136 tumor growth in a xenograft model.

< td class="col1 fwb"> Animal Model:

nu/nu mice (CAOV-3p53-UAA136 xenograft tumors)
Dosage:	0.3, 3 mg/kg (or 20 mg/kg once per week)
Administration:	Sc; five times per week
Result:	CAOV-33 _p53-UAA136 tumor growth was inhibited.