clitocine
- CAS NO.：105798-74-1
- Empirical Formula: C9H13N5O6
- Molecular Weight: 287.231
- MDL number: MFCD00875657
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is clitocine?
Definition
ChEBI: Clitocine is a N-glycosyl compound.
Biological Activity
Clitocine, an adenosine nucleoside analog derived from mushrooms, is a potent readthrough. As an inhibitor of nonsense mutations, it can induce the production of p53 protein in cells carrying p53 nonsense mutant alleles. It induces apoptosis in multidrug-resistant tumor cells by targeting Mcl-1. Has anticancer activity.
in vitro
Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough.
Clitocine (0-0.8 μM ; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. It (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis.
div>
in vivo
Citocine (0.3-3 mg/kg; sc; five times per week)-induced p53 inhibits CAOV-33 p53-UAA136 tumor growth in a xenograft model.
| nu/nu mice (CAOV-3p53-UAA136 xenograft tumors) | |
| Dosage: | 0.3, 3 mg/kg (or 20 mg/kg once per week) |
| Administration: | Sc; five times per week |
| Result: | CAOV-33 p53-UAA136 tumor growth was inhibited. |
Properties of clitocine
| form | Solid |
| color | White to off-white |
Safety information for clitocine
Computed Descriptors for clitocine
New Products
2-(2-aminoethyl) benzenesulfonamide Gemcitabine 3-benzoate impurity Dihydroxyphenylacetone Ornidazole EP impurity D Acetyl amino diol impurity Valsartan Benzyl Ester Impurity B N,N'-Dicyclohexylcarbodiimide 3-Bromo-2-Methyl-5-Nitropyridine 5-Bromo-3-Methyl-2-Pyridinecarboxylic acid 2-Amino-4-Methylpyridine 4-Aminopyridine 4-dimethylaminopyridineRelated products of tetrahydrofuran
You may like
-
4-(Methylnitrosoamino)-butanal NLT 95%View Details
339362-86-6 -
848696-99-1 NLT 95%View Details
848696-99-1 -
Ornidazole EP impurity A 1384752-15-1 NLT 95%View Details
1384752-15-1 -
615-81-6 Diisopropyl oxalate NLT 95%View Details
615-81-6 -
175481-38-6 Lacosamide EP Impurity F NLT 95%View Details
175481-38-6 -
S-Clopidogrel N-Methyl Impurity 1346605-15-9 NLT 95%View Details
1346605-15-9 -
Valsartan Related Compound A NLT 95%View Details
137862-87-4 -
Losartan Propyl BCFI 124750-49-8 NLT 95%View Details
124750-49-8