Clindamycin palmitate hydrochloride
- CAS NO.：25507-04-4
- Empirical Formula: C34H64Cl2N2O6S
- Molecular Weight: 699.85
- MDL number: MFCD03093716
- EINECS: 607-740-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-20 16:56:14
What is Clindamycin palmitate hydrochloride?
Description
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin . It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.
Chemical properties
White Solid
The Uses of Clindamycin palmitate hydrochloride
Clindamycin Palmitate is a semi-synthetic antibiotic with high bioavailability. Clindamycin Palmitate is an antibacterial.
The Uses of Clindamycin palmitate hydrochloride
antibacterial (tuberculostatic)
Definition
ChEBI: Clindamycin palmitate hydrochloride is a S-glycosyl compound.
brand name
Cleocin (Pharmacia & Upjohn).
General Description
Clindamycin palmitate hydrochloride (Cleocin Pediatric) isthe hydrochloride salt of the palmitic acid ester ofcleomycin. The ester bond is to the 2-hydroxyl group of thelincosamine sugar. The ester serves as a tasteless prodrugform of the antibiotic, which hydrolyzes to clindamycin inthe plasma. The salt form confers water solubility to theester, which is available as granules for reconstitution intoan oral solution for pediatric use. Although absorption of thepalmitate is slower than that of the free base, there is littledifference in overall bioavailability of the two preparations.Reconstituted solutions of the palmitate hydrochloride arestable for 2 weeks at room temperature. Such solutionsshould not be refrigerated because thickening occurs thatmakes the preparation difficult to pour.
Properties of Clindamycin palmitate hydrochloride
| Melting point: | 141-143°C |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
Safety information for Clindamycin palmitate hydrochloride
Computed Descriptors for Clindamycin palmitate hydrochloride
| InChIKey | GTNDZRUWKHDICY-ZLNNALEKSA-N |
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