CIRAZOLINE HYDROCHLORIDE
- CAS NO.：40600-13-3
- Empirical Formula: C13H17ClN2O
- Molecular Weight: 252.74
- MDL number: MFCD00274034
- EINECS: 2549953
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is CIRAZOLINE HYDROCHLORIDE?
Description
Cirazoline is an α1-adrenergic receptor (α1-AR) agonist (Kis = 120, 960, and 660 nM for recombinant α1A-, α1B-, and α1D-ARs, respectively, in CHO cell membranes). It acts as a full agonist at α1A- and a partial agonist at α1B- and α1D-ARs in vitro (EC50s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at α2-ARs with a pA2 value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum. Cirazoline (0.01-1 μg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats. It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months. It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 μg/kg but impairs performance at lower doses of 0.01-1 μg/kg.
The Uses of CIRAZOLINE HYDROCHLORIDE
Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice.
What are the applications of Application
Cirazoline hydrochloride is a selective α1 agonist
Biological Activity
Selective α 1 agonist. Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ .
Biochem/physiol Actions
Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys.
Storage
Store at RT
Properties of CIRAZOLINE HYDROCHLORIDE
| storage temp. | Store at RT |
| solubility | H2O: >35 mg/mL |
| form | solid |
| color | white |
Safety information for CIRAZOLINE HYDROCHLORIDE
Computed Descriptors for CIRAZOLINE HYDROCHLORIDE
New Products
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