CHOLINE MAGNESIUM TRISALICYLATE

Toxicity

Salicylate intoxication, known as salicylism, may occur with large doses or extended therapy. Common symptoms of salicylism include headache, dizziness, tinnitus, hearing impairment, confusion, drowsiness, sweating, vomiting, diarrhea, and hyperventilation. A more severe degree of salicylate intoxication can lead to CNS disturbances, alteration in electrolyte balance, respiratory and metabolic acidosis, hyperthermia, and dehydration.

The Uses of CHOLINE MAGNESIUM TRISALICYLATE

The antipyretic and analgesic effect of Choline magnesium trisalicylate is similar to that of aspirin, but the adverse reaction is less than that of aspirin, and the curative effect is better than that of aspirin and ibuprofen. It is indicated for the relief of symptoms of rheumatoid arthritis, osteoarthritis, and other arthritic conditions, both in the acute onset and in the long-term treatment of these diseases. The gastrointestinal reaction is small, so it is especially suitable for patients who cannot tolerate aspirin.

Background

Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28% .

Indications

Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.

Pharmacokinetics

Trisalicylate-choline is a non-steroidal anti-inflammatory drug (NSAID) that contains a combination of choline salicylate and magnesium salicylate. Does not affect platelet aggregation.

Side Effects

①Active peptic ulcer, hemophilia and allergic to salicylates should not be used. Pregnant women and children under 12 years old are prohibited. ②Use with caution in patients with chronic renal insufficiency and acute erosive gastritis. ③ This product should not be used at the same time as coumarin anticoagulant or heparin. Concomitant use with steroids or alcohol may increase ulcer bleeding. ④ Occasionally rash, fever and stomach discomfort.

Metabolism

Not Available