CHOLIC-2,2,4,4-D4 ACID
- CAS NO.：116380-66-6
- Empirical Formula: C24H36D4O5
- Molecular Weight: 412.6
- MDL number: MFCD00209701
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-04 14:24:59
What is CHOLIC-2,2,4,4-D4 ACID?
Description
Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid by GC- or LC-MS. Cholic acid is a primary bile acid. It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA; ) and taurocholic acid (TCA; ), respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid (DCA; ) by intestinal microbiota. It induces C. difficile colony formation in an agar dilution assay when used at a concentration of 0.1% w/v. Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats.
The Uses of CHOLIC-2,2,4,4-D4 ACID
Cholic Acid-d4 is a labelled analog of Cholic acid (C432600) which is a choleretic produced by, and isolated from liver cells.
Definition
ChEBI: Cholic acid-2,2,4,4-d4 is a bile acid.
Properties of CHOLIC-2,2,4,4-D4 ACID
| Melting point: | 200-201°C (lit.) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml |
| form | Solid |
| color | White to Off-White |
Safety information for CHOLIC-2,2,4,4-D4 ACID
Computed Descriptors for CHOLIC-2,2,4,4-D4 ACID
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