CHOLERA TOXIN

Synonym(s):Cholera enterotoxin;Cholera Toxin, Vibrio cholerae, Type Inaba 569B, Azide Free - CAS 9012-63-9 - Calbiochem;Choleragen;CTX

CAS NO.：9012-63-9
Empirical Formula: NULL
Molecular Weight: 0
MDL number: MFCD00130776
Update Date: 2026-05-27 22:50:03

What is CHOLERA TOXIN?

The Uses of CHOLERA TOXIN

Cholera Toxin from Vibrio cholerae has been used as a positive control in cAMP (cyclic AMP) assay for enterotoxins. It has been added as a supplement in cell culture media of primary tumors and epithelial cells.

Biochem/physiol Actions

Toxin consisting of an A subunit (27 kDa) surrounded by five B subunits (approximately 12 kDa each), which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein (Gαs), reducing GTPase activity and activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Also ADP-ribosylates transducin in the eye rod outer segments, inactivating its GTPase activity. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.

Properties of CHOLERA TOXIN

storage temp.	0-6°C
solubility	H2O: soluble10mg/mL
form	lyophilized powder
color	White to off-white

Safety information for CHOLERA TOXIN

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H332:Acute toxicity,inhalation H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P262:Do not get in eyes, on skin, or on clothing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.