CHLORMETHIAZOLE HYDROCHLORIDE

The Uses of CHLORMETHIAZOLE HYDROCHLORIDE

Chlormethiazole Hydrochloride was used in the study of effect of thiazole methiodide and hydrochloride fractions of thiamine upon the neuromuscular system.

What are the applications of Application

Chlormethiazole hydrochloride is potentiates GABAA receptor function

Biochem/physiol Actions

Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug.

Drug interactions

Potentially hazardous interactions with other drugs
Antipsychotics: enhanced sedative effects.
Antivirals: concentration possibly increased by ritonavir.
Cimetidine: inhibits metabolism of clomethiazole.

Metabolism

Clomethiazole is extensively metabolised, probably by first-pass metabolism in the liver with only small amounts appearing unchanged in the urine. The rate of elimination is decreased by about 30% in liver cirrhosis.