CHLORMETHIAZOLE HYDROCHLORIDE
- CAS NO.：6001-74-7
- Empirical Formula: C6H9Cl2NS
- Molecular Weight: 198.11336
- MDL number: MFCD00673948
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is CHLORMETHIAZOLE HYDROCHLORIDE?
The Uses of CHLORMETHIAZOLE HYDROCHLORIDE
Chlormethiazole Hydrochloride was used in the study of effect of thiazole methiodide and hydrochloride fractions of thiamine upon the neuromuscular system.
What are the applications of Application
Chlormethiazole hydrochloride is potentiates GABAA receptor function
Biochem/physiol Actions
Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug.
Drug interactions
Potentially hazardous interactions with other drugs
Antipsychotics: enhanced sedative effects.
Antivirals: concentration possibly increased by
ritonavir.
Cimetidine: inhibits metabolism of clomethiazole.
Metabolism
Clomethiazole is extensively metabolised, probably by first-pass metabolism in the liver with only small amounts appearing unchanged in the urine. The rate of elimination is decreased by about 30% in liver cirrhosis.
Properties of CHLORMETHIAZOLE HYDROCHLORIDE
| Melting point: | 130℃ |
| storage temp. | Desiccate at RT |
| solubility | H2O: >10 mg/mL, soluble |
| form | crystalline |
| color | off-white |
| Merck | 14,2384 |
| Stability: | Hygroscopic |
Safety information for CHLORMETHIAZOLE HYDROCHLORIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for CHLORMETHIAZOLE HYDROCHLORIDE
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