CHEMBRDG-BB 5280909

Synonym(s):1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol;VU0099704

CAS NO.：89159-60-4
Empirical Formula: C16H14N2O3
Molecular Weight: 282.29
MDL number: MFCD00593702
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 04:44:59

What is CHEMBRDG-BB 5280909?

Description

ML-354 is an indole-based, proteinase-activated receptor 4 (PAR4) antagonist (IC₅₀ = 140 nM) that exhibits 71-fold selectivity for PAR4 over PAR1 (IC₅₀ = 10 μM) in isolated human platelets.

The Uses of CHEMBRDG-BB 5280909

ML-354 is a selective protease activated receptor 4 ( PAR-4) antagonist used for its antithrombotic effects.

Biochem/physiol Actions

ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist.

Storage

Store at -20°C

References

[1]. wen, w., young, s., duvernay, m., schulte, m., nance, k., & melancon, b. et al. substituted indoles as selective protease activated receptor 4 (par-4) antagonists: discovery and sar of ml354. bioorganic & medicinal chemistry letters. 2014; 24(19): 4708-4713.

Properties of CHEMBRDG-BB 5280909

Melting point:	178-179 °C(Solv: 1,4-dioxane (123-91-1))
Boiling point:	544.0±50.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
pka	14.47±0.10(Predicted)
form	powder
color	white to beige

Safety information for CHEMBRDG-BB 5280909

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.