ceralifimod

CAS NO.：891859-12-4
Empirical Formula: C27H33NO4
Molecular Weight: 435.56
MDL number: MFCD28502037
SAFETY DATA SHEET (SDS)
Update Date: 2026-08-05 09:01:00

What is ceralifimod?

Description

Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P₁ and S1P₅ (K_is = 0.626 and 0.574 nM, respectively). It is selective for S1P₁ and S1P₅ over S1P_2-4 (K_is = >5,450, >5,630, and 28.8 nM, respectively). Ceralifimod induces calcium influx in CHO-K1 cells overexpressing S1P₁ (EC₅₀ = 1 nM) and cAMP accumulation in CHO-K1 cells overexpressing S1P₁ or S1P₅ (EC₅₀s = 0.027 and 0.33 nM, respectively). In vivo, ceralifimod (0.03 and 0.1 mg/kg) reduces paw edema in a rat model of collagen induced arthritis (CIA). It also delays disease onset and inhibits lymphocyte infiltration of the spinal cord in a rat model of experimental autoimmune encephalomyelitis (EAE) and prevents disease relapse in a non-obese diabetic mouse model of relapsing-remitting EAE.

Storage

Store at -20°C

Properties of ceralifimod

Boiling point:	595.9±50.0 °C(Predicted)
Density	1.172±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:5.0(Max Conc. mg/mL);11.48(Max Conc. mM)
form	A crystalline solid
pka	2.71±0.20(Predicted)
color	White to off-white

Safety information for ceralifimod

Computed Descriptors for ceralifimod

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