CAY10677

CAS NO.：1443253-20-0
Empirical Formula: C25H37N5
Molecular Weight: 407.59
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 17:10:26

What is CAY10677?

Description

Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Isoprenylcysteine carboxyl methyltransferase (Icmt) catalyzes the methylation of C-terminal prenylcysteine residues, the last step in this process. CAY10677 is an analog of the Icmt inhibitor cysmethynil that was developed for improved solubility and cell permeability.¹ CAY10677 inhibits Icmt with an IC₅₀ value of 0.86 μM and demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC₅₀s = 2.63 versus 27.4 μM, respectively) and human prostate cancer PC3 cells (IC₅₀s = 2.55 versus 25.2 μM, respectively).¹

References

1. Ramanujulu, P.M., Yang, T., Yap, S.Q., et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt) Eur. J. Med. Chem. 63,378-386(2013).

Properties of CAY10677

storage temp.	Store at -20°C
solubility	DMF: 16 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml
form	A crystalline solid

Safety information for CAY10677

Computed Descriptors for CAY10677

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