CAY10581

CAS NO.：1018340-07-2
Empirical Formula: C22H21NO4
Molecular Weight: 363.41
MDL number: MFCD18428034
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:59:05

What is CAY10581?

Description

The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in vitro and in cells, but at low (μM) potency. Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice. CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC₅₀ = 55 nM). It is a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT). CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours.

The Uses of CAY10581

CAY10581 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor.

What are the applications of Application

CAY10581 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor

Properties of CAY10581

Boiling point:	548.8±50.0 °C(Predicted)
Density	1.32±0.1 g/cm3(Predicted)
solubility	DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 3 mg/ml
form	A crystalline solid
pka	12.53±0.60(Predicted)

Safety information for CAY10581

Computed Descriptors for CAY10581

New Products

3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-Boc-3-(cyanomethyl)azetidine Dimedone 1-N-Boc-3-(aminoethyl)azetidine N-BOC-piperidine-4-carboxylic acid 4,6-Dichlororesorcinol 5-Amino-2-Bromo-3-Chloropyridine 2-Picolinic acid N-oxide 4-Butyl Resorcinol 2-Bromo-5-Chloropyridine 5-Bromo-2-Hydroxy-3-Nitro Pyridine 2-Amino-4-phenyl-thiazole N-(4-Bromophenyl)-2-chloroacetamide TRIFLOURO ACETICACID-D METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3