CAY10526

CAS NO.：938069-71-7
Empirical Formula: C12H7BrO3S
Molecular Weight: 311.15
MDL number: MFCD18432686
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:33

What is CAY10526?

Description

Prostaglandin E₂ (PGE₂) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE₂ during inflammation can be accounted for by increased expression of both cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1). CAY10526 is an inhibitor of PGE₂ production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE₂ production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC₅₀ value of 1.8 μM without any effect on COX-2 expression.

What are the applications of Application

CAY10526 is an inhibitor of PGE2 production

Properties of CAY10526

Boiling point:	561.7±50.0 °C(Predicted)
Density	1.889±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
form	A crystalline solid
pka	8.90±0.60(Predicted)
color	Off-white to yellow

Safety information for CAY10526

Computed Descriptors for CAY10526

New Products

3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-Boc-3-(cyanomethyl)azetidine Dimedone 1-N-Boc-3-(aminoethyl)azetidine N-BOC-piperidine-4-carboxylic acid 4,6-Dichlororesorcinol 5-Amino-2-Bromo-3-Chloropyridine 2-Picolinic acid N-oxide 4-Butyl Resorcinol 2-Bromo-5-Chloropyridine 5-Bromo-2-Hydroxy-3-Nitro Pyridine 2-Amino-4-phenyl-thiazole N-(4-Bromophenyl)-2-chloroacetamide TRIFLOURO ACETICACID-D METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3