Calcitriol-d6

Description

Calcitriol-d6 is intended for us as an internal standard for the quantification of calcitriol by GC- or LC-MS. Calcitriol is synthesized from 7-dehydro cholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy vitamin D₃, the principal circulating form of vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.

Chemical properties

Off-White to Pale Yellow Solid

The Uses of Calcitriol-d6

The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic

The Uses of Calcitriol-d6

1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d₆?can be used as an analytical standard for the quantitative analysis of dihydroxyvitamin D3?concentration in human serum via LC-MS.

What are the applications of Application

Calcitriol-d6 is a biologically active form of vitamin D3

General Description

1α,25-Dihydroxyvitamin D3?[1,25(OH)₂D₃], also known as calcitriol, plays a role in calcium and phosphate metabolism in humans. It also regulates insulin secretion and induces cellular differentiation.
1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d₆?is a deuterated vitamin D3 wherein C-26 and C-27 carbon methyl protons are replaced by deuterium.