C-(1H-INDOL-5-YL)-METHYLAMINE

Synonym(s):Indole-5-methanamine

CAS NO.：81881-74-5
Empirical Formula: C9H10N2
Molecular Weight: 146.19
MDL number: MFCD01719220
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:16:05

C-(1H-INDOL-5-YL)-METHYLAMINE Structural

What is C-(1H-INDOL-5-YL)-METHYLAMINE?

The Uses of C-(1H-INDOL-5-YL)-METHYLAMINE

5-(AMinoMethyl)indole has been used as reactant for preparation of:• and HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p751•

The Uses of C-(1H-INDOL-5-YL)-METHYLAMINE

5-(Aminomethyl)indole is used in the synthesis of Vigabatrin (V253000) bioisosteres as inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT) inhibitors.

The Uses of C-(1H-INDOL-5-YL)-METHYLAMINE

Reactant for preparation of:

HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p75
Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
SCIO-469-like compounds for the inhibition of p38 MAP kinase
4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors
Non-covalent thrombin inhibitors

Properties of C-(1H-INDOL-5-YL)-METHYLAMINE

Melting point:	114-122 °C
Boiling point:	335.6±17.0 °C(Predicted)
Density	1.199±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	17.07±0.30(Predicted)

Safety information for C-(1H-INDOL-5-YL)-METHYLAMINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.