Bromisoval

Chemical properties

White Solid

Originator

Bromisovalum,Linhai Duqiao Fine Chemical Factory

The Uses of Bromisoval

2-Bromo-3-methylbutyrylurea is a hypnotic and sedative drug marketed over the counter in Asian under various brand names.

Definition

ChEBI: An N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group.

Manufacturing Process

A mixture of 2 kg 2-bromoisovalerylbromide and 1 kg dry urea is heated at 70°C. Then to the reaction mixture is added sodium hydrogen carbonate. 2- Bromo-3-methylbutyrylurea is recrystallized from toluene or water, melting point 149°C.

brand name

Bromural (Knoll).

Therapeutic Function

Sedative, Hypnotic

World Health Organization (WHO)

Bromisoval is a monureide sedative of long standing. It remains available in several countries. However, it releases the bromide ion and prolonged usage can result in chronic bromide accumulation and intoxication.

Safety Profile

Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, and coma. A sedative and hypnotic agent. When heated to decomposition it emits very toxic fumes of Brand NOx

Purification Methods

Crystallise it from aqueous EtOH or toluene, and dry it in air. [Beilstein 3 H 63, 3 I 29, 3 II 51, 3 III 123, 3 IV 117.]