BREVETOXIN PBTX-3
Synonym(s):Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem;Pumiliotoxin, Dihydrobrevetoxin B
- CAS NO.：85079-48-7
- Empirical Formula: C50H72O14
- Molecular Weight: 897.1
- MDL number: MFCD00214096
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:21:20
What is BREVETOXIN PBTX-3?
General Description
Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.
Biochem/physiol Actions
Primary TargetVoltage-dependent Na+ channel activator
Safety Profile
A poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors.
Properties of BREVETOXIN PBTX-3
| Density | 1.190±0.06 g/cm3(Predicted) |
| storage temp. | -20C |
| solubility | DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| pka | 13.78±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for BREVETOXIN PBTX-3
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Environment GHS09 |
| GHS Hazard Statements |
H300:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. |
Computed Descriptors for BREVETOXIN PBTX-3
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