Brequinar

CAS NO.：96187-53-0
Empirical Formula: C23H15F2NO2
Molecular Weight: 375.37
MDL number: MFCD00866437
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 10:31:43

What is Brequinar?

The Uses of Brequinar

Antineoplastic.

Definition

ChEBI: Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, an antineoplastic agent, an antiviral agent, a pyrimidine synthesis inhibitor, an anticoronaviral agent and an antimetabolite. It is a member of biphenyls, a member of monofluorobenzenes, a quinolinemonocarboxylic acid and a monocarboxylic acid. It is a conjugate acid of a brequinar(1-).

Properties of Brequinar

Melting point:	355-357℃ (N,N-dimethylformamide water )
storage temp.	2-8°C
solubility	DMSO:25.9(Max Conc. mg/mL);70.0(Max Conc. mM)
form	powder to crystal
pka	pKa 4.45(H2O t=RT I=0.10) (Uncertain)
color	White to Light yellow
CAS DataBase Reference	96187-53-0

Safety information for Brequinar

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.