BRD4770

Synonym(s):2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester

CAS NO.：1374601-40-7
Empirical Formula: C25H23N3O3
Molecular Weight: 413.47
MDL number: MFCD23143627
EINECS: 802-776-3
Update Date: 2026-06-03 11:24:09

What is BRD4770?

The Uses of BRD4770

BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 μM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both anchorage-dependent and –independent proliferation of PANC-1 cells.[Cayman Chemical]

Definition

ChEBI: 2-benzamido-1-(3-phenylpropyl)-5-benzimidazolecarboxylic acid methyl ester is a member of benzimidazoles.

Biochem/physiol Actions

BRD4770 is a selective inhibitor of the histone methyltransferase G9a. BRD4770 blocks lysine residue 9 methylation of histone H3 without inducing apoptosis. In PANC-1 cells, BRD4770 activates the ataxia telangiectasia mutated (ATM) pathway, induces senescence and inhibits anchorage-dependent and -independent growth.

Properties of BRD4770

Density	1.21±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble5mg/mL, clear (warmed)
pka	12.12±0.43(Predicted)
form	powder
color	white to beige
CAS DataBase Reference	1374601-40-7

Safety information for BRD4770

Computed Descriptors for BRD4770

New Products

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