Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Synonym(s):(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad;LY 354740 - CAS 176199-48-7 - Calbiochem

CAS NO.：176199-48-7
Empirical Formula: C8H11NO4
Molecular Weight: 185.18
MDL number: MFCD04113018
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:22:51

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Structural

What is Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)?

The Uses of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Treatment ofgeneral anxiety disorders and smoking cessation (metabotropic glutamate agonist).

The Uses of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

LY 354740 is a highly selective and potent agonist of group II mGluR.

What are the applications of Application

LY 354740 is a highly selective and potent agonist of group II mGluR

Definition

ChEBI: Eglumetad is a L-alpha-amino acid.

Biological Activity

Highly selective and potent agonist of group II mGlu receptors (EC 50 values are 5.1 and 24.3 nM at mGlu 2 and mGlu 3 receptors respectively and > 100000 nM at mGlu 4 , mGlu 7 , mGlu 1a and mGlu 5a receptors). Displays antianxiety and antiaddictive activity in vivo . Orally and systemically active.

Storage

+4°C

Properties of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Melting point:	270-271 °C
Boiling point:	376.4±32.0 °C(Predicted)
Density	1.569
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	H2O : 6.33 mg/mL (34.18 mM; Need ultrasonic and warming)
form	Powder
pka	2.06±0.40(Predicted)
color	White to off-white

Safety information for Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Synonym(s):(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad;LY 354740 - CAS 176199-48-7 - Calbiochem

What is Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)?

The Uses of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

The Uses of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

What are the applications of Application

Definition

Biological Activity

Storage

Properties of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Safety information for Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Computed Descriptors for Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

New Products

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