BI-6C9

CAS NO.：791835-21-7
Empirical Formula: C23H25N3O4S2
Molecular Weight: 471.59
MDL number: MFCD07784498
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-14 16:49:18

What is BI-6C9?

The Uses of BI-6C9

BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 μM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 μM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.

What are the applications of Application

BI-6C9 is a tBid inhibitor that possesses antiapoptotic properties

Properties of BI-6C9

Density	1.36±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: 24 mg/mL, soluble
form	solid
pka	11.58±0.50(Predicted)
color	off-white

Safety information for BI-6C9

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for BI-6C9

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