BI 6015

Synonym(s):2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole, Hepatocyte Nuclear Factor4 Antagonist;HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem

CAS NO.：93987-29-2
Empirical Formula: C15H13N3O4S
Molecular Weight: 331.35
MDL number: MFCD04406654
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:28

What is BI 6015?

Description

BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics.2 BI-6015 represents the first small molecule tool for pharmacologic modulation of HNF4α activity.2 Cell permeable.

The Uses of BI 6015

BI 6015 is a known HNF4α antagonist that represses the expression of known HNF4α target genes. Studies have shown that BI6015 are also capable of exhibiting selective cytotoxic activities against numerous tumor cell lines.

Storage

Store at -20°C

References

1) Wang et al. (2000), Hepatocyte Nuclear Factor 4α Regulates the Expression of Pancreatic β-Cell Genes Implicated in Glucose Metabolism and Nutrient-induced Insulin Secretion; J. Biol. Chem., 275 35953 2) Kiselyuk et al. (2012), HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promotor; Chem. Biol., 19 806

Properties of BI 6015

Boiling point:	570.6±60.0 °C(Predicted)
Density	1.45±0.1 g/cm3(Predicted)
storage temp.	+2C to +8C
solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
form	Beige powder
pka	0.88±0.10(Predicted)
color	Tan
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.