Benzylidenemalononitrile

Chemical properties

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The Uses of Benzylidenemalononitrile

Benzylidenemalononitrile was used in fluorescence-based assay for determination of soluble methane monooxygenase activity in solution.

What are the applications of Application

Benzylidenemalononitrile is a potential substrate for soluble methane monooxygenase

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 4819, 1984 DOI: 10.1021/jo00199a014
Tetrahedron Letters, 23, p. 4927, 1982 DOI: 10.1016/S0040-4039(00)85749-4

General Description

Benzylidenemalononitrile undergoes rapid and catalyst-free solid/vapor reaction with primary alkyl amines to yield N-benzylidene-amine. It undergoes addition reaction with octyl- and decylzirconocene chloride. It is a potential substrate for soluble methane monooxygenase.

Purification Methods

Recrystallise the nitrile from EtOH [Bernasconi et al. J Am Chem Soc 107 3612 1985]. It has max at 307nm (EtOH). [Beilstein 9 H 895, 9 II 640, 9 III 4380, 9 IV 3462.]