Benzyl thiocyanate

Synonym(s):Benzyl rhodanide;Benzyl thiocyanate;Thiocyanic acid benzyl ester, Benzyl rhodanide

CAS NO.：3012-37-1
Empirical Formula: C8H7NS
Molecular Weight: 149.21
MDL number: MFCD00001832
EINECS: 221-144-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is Benzyl thiocyanate?

Description

Benzyl thiocyanate undergoes regioselective bond dissociation during its electrochemical reduction in acetonitrile at an inert electrode. It is added to stimulate the chlortetracycline biosynthesis during industrial fermentations. It undergoes biotransformation into dibenzyl disulphide by Streptomyces aureofaciens.

Chemical properties

ALMOST WHITE TO YELLOW CRYSTALS OR CRYST. POWDER

The Uses of Benzyl thiocyanate

Benzyl Thiocyanate is found to increase the protein production of Streptomyces aureofaciens. Inhibits methylazoxymethanol acetate-induced intestinal carcinogenesis and reduces unscheduled DNA synthesi s for some genotoxic carcinogens in rats.

The Uses of Benzyl thiocyanate

Benzyl thiocyanate was used to study the effects of various dietary compounds on the α-hydroxylation of N-nitrosopyrrolidine in male F344 rats in vitro.

What are the applications of Application

Benzyl thiocyanate is effective against MAM-induced intestinal carcinogenesis in rats

What are the applications of Application

Benzyl thiocyanate was used to study the effects of various dietary compounds on the α-hydroxylation of N-nitrosopyrrolidine in male F344 rats in vitro.

Definition

ChEBI: Benzyl thiocyanate is a member of thiocyanates.

Synthesis Reference(s)

Synthesis, p. 184, 1977
Tetrahedron Letters, 18, p. 4417, 1977 DOI: 10.1016/S0040-4039(01)83524-3

General Description

Hazard

Strong irritant to skin, tissue. Moderate fire hazard.

Safety Profile

Poison by subcutaneous andintraperitoneal routes. Whenheated to decomposition it emits very toxic fumes ofNOx, SOx, and CN??.

Purification Methods

Crystallise the thiocyanate from EtOH or aqueous EtOH. [Beilstein 6 H 460, 6 IV 2680.]

Properties of Benzyl thiocyanate

Melting point:	39-41 °C (lit.) 39-41 °C
Boiling point:	230-235 °C (lit.)
Density	1.32
refractive index	1.6000 (estimate)
Flash point:	>230 °F
storage temp.	Store at <= 20°C.
solubility	diethyl ether: soluble0.5g/10 mL, clear to very faintly turbid, colorless to almost colorless
form	Solid
color	Orange-red crystals or solid
Water Solubility	insoluble
Sensitive	Moisture Sensitive
BRN	1859726
CAS DataBase Reference	3012-37-1(CAS DataBase Reference)
NIST Chemistry Reference	Thiocyanic acid benzyl ester(3012-37-1)
EPA Substance Registry System	Thiocyanic acid, phenylmethyl ester (3012-37-1)

Safety information for Benzyl thiocyanate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection.