Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

CAS NO.：2003260-55-5
Empirical Formula: C25H22N2O2
Molecular Weight: 382.45
MDL number: MFCD31382180
Update Date: 2026-08-07 18:09:57

What is Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-?

Biological Activity

NCGC00244536 is a potent KDM4B inhibitor with IC50 of 10 nM.

in vitro

NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC ₅₀ =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4 . NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC ₅₀ s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC ₅₀ s.

in vivo

Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis .

Properties of Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

Boiling point:	646.9±55.0 °C(Predicted)
Density	1?+-.0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF:30.0(Max Conc. mg/mL);78.44(Max Conc. mM) DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM) DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM) Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM)
form	A crystalline solid
pka	4.81±0.40(Predicted)
color	Light yellow to green yellow

Safety information for Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-

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