Benserazide hydrochloride

Description

Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.

Chemical properties

White Crystalline Solid

The Uses of Benserazide hydrochloride

Inhibitor of L-aromatic amino acid decarboxylaseBenserazide hydrochloride is used as an antiparkinsonian. It is a peripheral decarboxylase inhibitor. It is used as an inhibitor for aromatic L-aminoacid decarboxylase. Further, it serves as an inhibitor of tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH) inhibitor.

The Uses of Benserazide hydrochloride

Used as antiparkinsonian. A peripheral decarboxylase inhibitor

The Uses of Benserazide hydrochloride

Antiparkinsonian;DOPA decarboxylase inhibitor

What are the applications of Application

Benserazide?HCl (Ro 4-4602) is an aromatic L-aminoacid decarboxylase inhibitor

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of park nsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions whe given alone.

General Description

Benserazide is a peripheral decarboxylase inhibitor.

Biochem/physiol Actions

Inhibitor of L-aromatic amino acid decarboxylase.