BAY707)

CAS NO.：2109805-96-9
Empirical Formula: C15H20N4O2
Molecular Weight: 288.34
MDL number: MFCD31814430
Update Date: 2026-03-12 15:35:02

What is BAY707)?

Biological Activity

BAY-707 is a substrate-competitive, highly selective inhibitor of MTH1(NUDT1) with IC50 of 2.3 nM. It has a favorable pharmacokinetic profile compared to other MTH1 compounds and is well tolerated in mice, but the experiments clearly lack in vitro or in vivo anticancer efficacy.

in vivo

Bay-077 (orally adminstation; 50-250 mg/kg; 2 weeks) exhibits superior biochemical potency, cellular target engagement, and a pharmacokinetic profile to other MTH1 tool compounds, But Bay-077 exerts no anticancer efficacy either in mono- or in combination therapies in CT26 and NCI-H460 mice model.

Storage

Store at -20°C

Properties of BAY707)

Density	1.225±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:28.83(Max Conc. mg/mL);100.0(Max Conc. mM) Ethanol:2.88(Max Conc. mg/mL);10.0(Max Conc. mM)
form	Solid
pka	14.36±0.40(Predicted)
color	Light yellow to khaki

Safety information for BAY707)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for BAY707)

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