AZD-2858
- CAS NO.：486424-20-8
- Empirical Formula: C21H23N7O3S
- Molecular Weight: 453.52
- MDL number: MFCD26397072
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-08-04 11:17:55
What is AZD-2858?
The Uses of AZD-2858
AZD 2858 is a highly selective glycogen synthase kinase-3β (GSK3β) inhibitor used in the treatment of neurological diseases such as Alzheimer’s (1).
Definition
ChEBI: AZD2858 is a member of the class of pyrazines that is pyrazine substituted by (pyridin-3-yl)aminocarbonyl, amino, and 4-(4-methylpiperazine-1-sulfonyl)phenyl groups at positions 2, 3 and 6, respectively. It is a potent inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.9 and 4.9 nM, respectively) and increases bone mass (via Wnt activation) in rats. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, an antineoplastic agent, a bone density conservation agent and a Wnt signalling activator. It is a member of pyrazines, a secondary carboxamide, a member of pyridines, a N-methylpiperazine, a sulfonamide and an aromatic amine.
Storage
Store at -20°C
Properties of AZD-2858
| Density | 1.408±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20° C |
| solubility | DMSO:8.0(Max Conc. mg/mL);17.64(Max Conc. mM) |
| form | A crystalline solid |
| pka | 7.17±0.70(Predicted) |
| color | Green to khaki |
Safety information for AZD-2858
Computed Descriptors for AZD-2858
New Products
Cyclobutanone (R)-(-)-2-Amino-1-propanol Fmoc-OSu 5-bromo-4-fluoro-2-nitrobenzaldehyde 2-Amino-2-(4-methylphenyl)acetic acid 1-(2-Chloroethyl)pyrrolidine Hydrochloride 2,4-Dihydroxybenzaldehyde Obidoxime hydrochloride API Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Dipropyl disulfide N-Vinylformamide 4 pentyn 1 ol Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
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