ATN-224

CAS NO.：649749-10-0
Empirical Formula: C5H14MoNOS4-
Molecular Weight: 328.36
MDL number: MFCD25976790
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-14 16:49:18

What is ATN-224?

Description

ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC₅₀s = 2.91 and 3.51 μM in human and mouse blood cells, respectively, in vitro). ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC₅₀s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC₅₀s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL. In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice. It also inhibits angiogenesis in a mouse model (IC₅₀s = 1.50-3 mg/kg via gavage).

Properties of ATN-224

storage temp.	Store at -20°C
solubility	DMSO:20.0(Max Conc. mg/mL);46.24(Max Conc. mM) DMSO:PBS (pH 7.2):0.5(Max Conc. mg/mL);1.16(Max Conc. mM)
form	A crystalline solid
color	Pink to red

Safety information for ATN-224

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for ATN-224

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