ATN-224
- CAS NO.：649749-10-0
- Empirical Formula: C5H14MoNOS4-
- Molecular Weight: 328.36
- MDL number: MFCD25976790
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-08-05 09:01:00
What is ATN-224?
Description
ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC50s = 2.91 and 3.51 μM in human and mouse blood cells, respectively, in vitro). ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC50s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC50s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL. In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice. It also inhibits angiogenesis in a mouse model (IC50s = 1.50-3 mg/kg via gavage).
Properties of ATN-224
| storage temp. | Store at -20°C |
| solubility | DMSO:20.0(Max Conc. mg/mL);46.24(Max Conc. mM) DMSO:PBS (pH 7.2):0.5(Max Conc. mg/mL);1.16(Max Conc. mM) |
| form | A crystalline solid |
| color | Pink to red |
Safety information for ATN-224
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ATN-224
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