ASP-9521

CAS NO.：1126084-37-4
Empirical Formula: C19H26N2O3
Molecular Weight: 330.42
MDL number: MFCD30532740
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 06:11:44

What is ASP-9521?

Description

ASP9521 is an inhibitor of 17β-hydroxysteroid dehydrogenase type 5/aldo-keto reductase 1C3 (17β-HSD5/AKR1C3; IC₅₀ = 120 nM). It is selective for 17β-HSD5/AKR1C3 over AKR1C2 (IC₅₀ = 20 μM). ASP9521 inhibits conversion of androstenedione into testosterone by 17β-HSD5/AKR1C3 (IC₅₀s = 11 and 49 nM for human and cynomolgus monkey enzymes, respectively). It inhibits androstenedione-dependent production of prostate specific androgen (PSA) in and proliferation of LNCaP cells expressing 17β-HSD5/AKR1C3. ASP9521 (3 and 10 mg/kg) inhibits androstenedione-induced intratumor testosterone production in a CWR22R prostate cancer mouse xenograft model.

The Uses of ASP-9521

ASP 9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). AKR1C3 is a promising therapeutic target in castration-resistant prostate cancer

Properties of ASP-9521

Boiling point:	543.9±30.0 °C(Predicted)
Density	1.183±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO:52.26(Max Conc. mg/mL);158.16(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);30.26(Max Conc. mM) DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.51(Max Conc. mM) Ethanol:36.35(Max Conc. mg/mL);110.01(Max Conc. mM)
form	A crystalline solid
pka	15.23±0.29(Predicted)
color	Light yellow to yellow

Safety information for ASP-9521

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.