Amenamevir

CAS NO.：841301-32-4
Empirical Formula: C24H26N4O5S
Molecular Weight: 482.55
MDL number: MFCD19443709
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-22 18:57:36

What is Amenamevir?

Description

Amenamevir is an antiviral inhibitor of herpes simplex virus 1 (HSV-1) helicase-primase complex activity. It inhibits recombinant HSV-1 helicase with an IC₅₀ value of 0.078 μM and recombinant HSV-1 primase when used at concentrations greater than or equal to 0.03 μM. Amenamevir inhibits replication of varicella-zoster virus (VZV), HSV-1, and HSV-2 in human embryonic fibroblast (HEF) cells (EC₅₀s = 0.047, 0.036, and 0.028 μM, respectively) and is not cytotoxic to HEF cells with a 50% cytotoxic concentration (CC₅₀) of greater than 30 μM. Amenamevir also inhibits replication of clinical VZV isolates in HEF cells (EC₅₀s = 0.038-0.10 μM). In vivo, it increases survival of cutaneously HSV-1-infected mice in a zosteriform-spread model of progressive HSV-1 infection (ED₅₀ = 1.9 mg/kg twice per day).

The Uses of Amenamevir

Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC50 of 14 ng/mL.

Properties of Amenamevir

Density	1.360±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.08(Max Conc. mM) DMF:2.0(Max Conc. mg/mL);4.14(Max Conc. mM)
form	A solid
pka	12.60±0.70(Predicted)
color	White to off-white

Safety information for Amenamevir

Computed Descriptors for Amenamevir

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