ASARININ
- CAS NO.：133-04-0
- Empirical Formula: C20H18O6
- Molecular Weight: 354.35
- MDL number: MFCD00198067
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-24 17:36:03
What is ASARININ?
Description
Asarinin is a lignan that has been found in A. sieboldii. It is an epimer of sesamin and a noncompetitive inhibitor of Δ5-desaturase (Ki = 0.28 mM). It is selective for Δ5-desaturase over Δ6- and Δ9-desaturase. Asarinin is cytotoxic to A2780 and SKOV3 ovarian cancer cells (IC50s = 38.45 and 60.87 μM, respectively) but not immortalized ovarian surface epithelial cells (IC50 = >200 μM). It induces apoptosis and activates caspase-3, -8, and -9 in A2780 and SKOV3 cells.
The Uses of ASARININ
l-Asarinin in combination with pellitorine is a potential larvicides for the control of insecticide-resistant mosquito populations. Possesses antimicrobial activity.
Properties of ASARININ
| Melting point: | 121° |
| Boiling point: | 504.4±50.0 °C(Predicted) |
| alpha | D20 -118.6°; D23 -122° (chloroform) |
| Density | 1.385±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), DMSO (Slightly, Sonicated) |
| form | Solid |
| color | White to Off-White |
Safety information for ASARININ
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ASARININ
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