AS2553627

CAS NO.：1251906-10-1
Empirical Formula: C18H19N5O
Molecular Weight: 321.38
Update Date: 2025-04-18 09:51:06

What is AS2553627?

Description

AS2553627 is a novel JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts. AS2553627 potently inhibited JAK kinases but showed no inhibition of other kinases, including TCR-associated molecules. In a rat cardiac transplant model, oral administration of AS2553627 alone or co-administration with a sub-therapeutic dose of tacrolimus effectively prolonged cardiac allograft survival, suggesting the efficacy in treating acute rejection. AS2553627 may be a therapeutic candidate for the prevention of not only acute but also chronic rejection in cardiac transplantation.

Properties of AS2553627

Boiling point:	666.3±55.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
pka	6.12±0.60(Predicted)

Safety information for AS2553627

Computed Descriptors for AS2553627

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