ARRY-334543
- CAS NO.：845272-21-1
- Empirical Formula: C22H19ClN6O2S
- Molecular Weight: 466.94
- MDL number: MFCD20275099
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-20 19:14:41
What is ARRY-334543?
The Uses of ARRY-334543
ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively.
What are the applications of Application
ARRY334543 is a potent and selective EGFR phosphorylation inhibitor
Enzyme inhibitor
This ErbB1/2 inhibitor (FW = 466.94 g/mol; CAS 845272-21-1), also named (R)-N4 -(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6 -(4-methyl-4,5- dihydrooxazol-2-yl)quinazoline-4,6-diamine, selectively targets the intrinsic protein kinase activities of ErbB1, or Epidermal Growth Factor Receptor (EGFR), IC50 = 7 nM and ErbB2, or Human Epidermal growth factor Receptor (HER2), IC50 = 2 nM. ARRY-334543 also reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2.
Properties of ARRY-334543
| Boiling point: | 637.1±65.0 °C(Predicted) |
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (107.08 mM; Need ultrasonic) |
| form | Powder |
| pka | 6.54±0.70(Predicted) |
| color | Off-white to yellow |
| CAS DataBase Reference | 845272-21-1 |
Safety information for ARRY-334543
Computed Descriptors for ARRY-334543
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