apogossypol
- CAS NO.：66389-74-0
- Empirical Formula: C28H30O6
- Molecular Weight: 462.53
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:55:34
What is apogossypol?
Biological Activity
(+)-Apogossypol is a pan-BCL-2 antagonist that binds to Mcl-1, Bcl-2 and Bcl-xL with EC50 of 2.6, 2.8 and 3.69 μM, respectively.
in vitro
In agreement with NMR binding and fluorescence polarization assays (FPAs) data, (+)-Apogossypol displays potent binding affinity to Bcl-xL with K d values of 1.7 μM.
in vivo
Due to its modified structure, (+)-Apogossypol is expected to exhibit lower toxicity while maintaining the significant anti-growth and anti-tumor activities in vitro, similar to those of Gossypol.
Properties of apogossypol
| Melting point: | 118-123 °C |
| Boiling point: | 673.3±50.0 °C(Predicted) |
| Density | 1.335±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | >16.2mg/mL in DMSO with gentle warming |
| form | Powder |
| pka | 8.03±0.50(Predicted) |
Safety information for apogossypol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for apogossypol
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