AP1903

CAS NO.：195514-63-7
Empirical Formula: C78H98N4O20
Molecular Weight: 1411.63
MDL number: MFCD25976784
EINECS: 604-604-1
Update Date: 2026-07-27 17:00:41

What is AP1903?

Biological Activity

AP1903 (Rimiducid) is a dimerizing agent that acts by cross-linking the FKBP domain, initiating Fas signaling and causing apoptosis.It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.

in vitro

The human fibrosarcoma line HT1080 is engineered to express stably a fusion protein comprising a myristoylation sequence, two copies of F36V-FKBP, and the human first apoptosis signal (Fas) intracellular domain. Rimiducid (AP1903) elicits potent and dose-dependent apoptotic death of these engineered cells in culture, with an EC ₅₀ of ≈0.1 nM. Maximal killing occurred in the presence of 3 to 10 nM Rimiducid (AP1903), and the IC ₅₀ is approximately 0.2 nM. LV′VFas-transduced T lymphocytes expressing high levels of CD25 (top panel) are eliminated by with 66%±7.5% (n=10) efficiency. When cells are examined after CD25 expression returned to basal levels, 63%±4.7% (n=9) killing is observed after Rimiducid treatment.

in vivo

AP1903 elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg /kg.

Storage

Store at -20°C

Properties of AP1903

Boiling point:	1307.5±65.0 °C(Predicted)
Density	1?+-.0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO:97.05(Max Conc. mg/mL);68.75(Max Conc. mM) Ethanol:120.58(Max Conc. mg/mL);85.42(Max Conc. mM)
form	A solid
pka	13.70±0.46(Predicted)
color	White to light yellow

Safety information for AP1903

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for AP1903

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