Anti-VPS22

The Uses of Anti-VPS22

Rabbit Anti-SNF8 antibody can be used for western blot applications at a concentration of 0.5μg/ml.

General Description

SNF8 (EAP30 or VPS22) forms a part of the ESCRT-II complex that regulates the endocytosis of ubiquitinated proteins. EAP30 is known to facilitate the endosomal sorting of chemokine and growth factor receptors that are marked for lysosomal degradation. SNF8 is also a part of the ELL complex that is involved in RNA polymerase II-mediated transcriptional elongation.
Rabbit Anti-SNF8 antibody recognizes bovine, zebrafish, chicken, human, mouse, rat, and canine SNF8.

Biochem/physiol Actions

ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML). In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL′s inhibitory activity in vitro.SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM].