Anti-Ubiquitin thioesterase 28 antibody produced in rabbit

The Uses of Anti-Ubiquitin thioesterase 28 antibody produced in rabbit

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

General Description

Ubiquitin specific peptidase 28 (USP28) is a deubiquitinating enzyme and belongs to the ubiquitin?processing enzymes (UBP) family. It is made up of four domains, such as cysteine box (UCH-1), histidine box (UCH-2), ubiquitin interacting motif (UIM) and coiled-coiled (CC) domain. USP28 is located at 11q23 on the human chromosome.

Biochem/physiol Actions

USP28 (Ubiquitin specific peptidase 28) is a deubiquitinating protein involved in various cellular processes such as c-MYC regulation, DNA damage response, and cancer progression. It gets recruited at the double strand break site to stabilize various factors required for DNA damage response (DDR). It is an effective prognostic biomarker of human bladder cancer. It also acts as a negative regulator in the deubiquitinating activity. Elevated USP28 expression has been reported in the colon and breast carcinomas.