Anti-RNA-binding protein 7

The Uses of Anti-RNA-binding protein 7

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

General Description

RNA binding motif protein 7 is ubiquitously expressed and interacts with RNA splicing factors. It contains an RRM (RNA Recognition Motif) consensus sequence. Based on its expression in rodent testis, its role has been attributed to pre-mRNA processing during the development of spermatocytes.

Biochem/physiol Actions

The gene RBM7 (RNA binding motif protein 7) forms a subunit of the NEXT (Nuclear Exosome Targeting) complex, which is involved in PROMPT (Promoter Upstream Transcripts) turnover. The encoded protein is found to interact with two essential splicing factors, SAP145 and SRp20 and SKIV2L2 with U4/U6, and may target U1 and U2 snRNAs. The RRM (RNA recognition motif) of RBM7 recognizes the oligo(U) stretches in RNA and facilitates the binding of NEXT to snRNAs.