ANTI-HISTAMINE

The Uses of ANTI-HISTAMINE

Anti-Histamine antibody produced in rabbit has been used:

• in immunohistochemistry
• to test immunohistochemical reactions of Pseudophoxinus antalyae digestive system tissues
• in immunocytochemical assays
• in immunofluorescence assays

World Health Organization (WHO)

Antihistamines have been used for many years as a treatment for hypersensitive reactions. The topical application of antihistamines is, however, associated with an unacceptable incidence of skin irritation and hypersensitivity reactions.

General Description

Histamine, (2-(4-Imidazolyl)ethylamine), is a widely distributed substance in peripheral tissues. Histamine is localized in mast cells, neuronal cells and neuroendocrine cells of the gastric tract. It is also expressed in lungs, kidney, in cerebrovascular endothelial cells and throughout the peripheral nervous system.

Biochem/physiol Actions

Histamine, (2-(4-Imidazolyl)ethylamine) mediates a variety of physiological activities including inflammation, gastric acid secretion and smooth muscle contraction. It is also implicated in modulation of cell growth and differentiation, during embryogenesis, and tumor growth and in the suppression of mitogen-induced lymphocyte proliferation. In the central nervous system (CNS), histamine acts as a neurotransmitter/ neuromodulator of various brain activities.