Anti-Deadenylation nuclease antibody produced in rabbit

The Uses of Anti-Deadenylation nuclease antibody produced in rabbit

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

Biochem/physiol Actions

PARN (Poly(A)-specific ribonuclease) is a 3′-exoribonuclease belonging to the deadenylase family. It consists of three functional RNA-binding domains: the catalytic nuclease domain, the R3H domain and the RRM domain. It is a dimer in structure with molecular weight of 161kDa. It exerts RNA-binding ability and catalytic functions. It is majorly involved in the degradation of mRNA poly(A) tails. It identifies the adenosine at the active site during poly(A) degradation. It can also degrade poly(U) site, which is a vital step in RNA stability.